Evening Primrose Oil 500mg
Penjelasan Singkat :
- Mengandung 500mg Evening Primerose oil murni
- Kaya akan kandungan Linoleic acid dan GLA
- Membantu memelihara kesehatan?
- Dapat digunakan sebagai suplemen kesehatan tubuh
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Oenothera Biennis L. - Evening Primrose (EP) telah lama digunakan semenjak jaman India kuno di Amerika. Kemudian Evening Primrose dibawa ke benua Eropa pada tahun 1700 dan dikenal dengan sebutan "Kingdom drug" (obat kerajaan). Walaupun khasiatnya yang luar biasa tidak ada yang tahu rahasia kemanjuran dari Evenening Primrose sampai dengan abad 19. Pada tahun 1960 setelah diketemukan Prostaglandin (PG).
Pada tahun 1960 para peneliti menemukan bahwa Evening Primrose kaya akan kandungan Linoleic Acid (lebih dari 70%) dan Gamma-linolenic Acid (GLA7 7%) yang bertanggung jawab dalam pembentukan lemak Prostaglandin (PGE) yang berperan sangat penting dalam tubuh kita. Linoleic acid dan Gamma-linilenic acid berperan penting dalam tubuh kita tetapi tidak dapat dibentuk dalam tubuh kita, sehingga kedua lemak ini dikenal dengan sebutan EFA ( Essential Fatty Acid)
EFA merupakan salah satu komposisi penting yang terdapat pada sel kita, sehingga kekuarangan EFA dapat berakibat fatal bagi sel dan organ tubuh kita. Biasanya kebutuhan EFA kita dipenuhi dari konsumsi makanan sehari - hari. Tetapi kadang konsumsi makanan kita sehari - hari kurang akan kandungan EFA dan juga seiring bertambahnya umur kita semakin sulit bagi tubuh kita untuk memenuhi kebutuhan EFA. Dengan mengkonsumsi Evening Primrose Oil maka akan membantu tubuh kita untuk memenuhi kebutuhan EFA serta membantu melindungi kesehatan jantung kita.
Hasil Uji Klinis:
Berdasarkan hasil uji klinis ditemukan beberapa khasiat dari Evening Primrose oil sebagai berikut :
Mengatasi Arteriosklerosis dan Penyakit Jantung Koroner
Telah terbukti pada hasil uji klinis pada kelinci bahwa peningkatan PGE dapat membantu mengatasi penyakit jantung koroner, arteriosklerosis (pengerasan pembuluh arteri), dan membantu mengurangi hipertensi. Berdasarkan hasil penelitian dari 228 pasien yang mengkonsumsi Evening Primrose Oil selama 4 - 6 minggu dapat menurunkan kadar kolesterol jahat (LDL) dan meningkatkan kolesterol baik (HDL) sebanyak 55,3%
Mengatasi Penyumbatan pembuluh arteri
Berdasarkan hasil uji klinis Evening Primrose Oil dapat mengurangi penyumbatan pada pembuluh arteri, serta mengurangi gejara nyeri di dada (angina pectoris) pada penderita jantung koroner.
Membantu penderita Diabetes
Berdasarkan hasil penelitian terhadap binatang yang menderita Diabetes Melitus, dengan mengkonsumsi Evening Primrose Oil dapat membantu menurunkan kadar gula darah. Selain itu diketahu pula bahwa penderita Diabetes umumnya mengalami kekurangan EPA karena sulitnya bagi tubuh untuk menyerap EPA, dengan kekurangan EPA dapat menyebabkan komplikasi pada berbagai macam penyakit seperti jantung koroner, tekanan darah tinggi dan berbagai penyakit lainnya.
Mengatasi Kegemukan
Evening Primrose Oil juga ditemukan dapat membantu mengurangi berat badan, dengan membantu meningkatkan metabolisme tubuh serta meluruhkan lemak tubuh. Baru - baru ini banyak warga Jepang yang mengatakan khasiat dari Evening Primrose Oil yang dapat membuat kulit tetap terlihat muda, mengurangi berat badan mereka dan membuat mereka bahagia
Mengatasi Premesntrual Syndrome (PMS)
Berdasarkan hasil penelitian terhadap 68 wanita yang mengalami nyeri saat haid sangat parah pada St. Thomas Medical School menyebutkan bahwa 2/3 nya mengalami penyembuhan total dan 22% persen mengalami peningkatan.
Mengatasi Atopic Eczema
Pasien yang menderita Atopic Eczema (Kulit merah dan gatal yang umumnya terjadi pada anak dibawah 5 tahun) dengan pengobatan selama 12 minggu dapat memperoleh peningkatan yang luar biasa. Hal ini disebabkan penyakit kulit tersebut disebabkan oleh anak kekurangan GLA pasa saat berganti dari susu ASI menjadi susu kaleng. Pada susu ASI mengandung GLA sedangkan pada susu kaleng tidak mengandung GLA. Dengan mengkonsumsi Evening Primrose Oil dapat membantu memenuhi kebutuhan GLA pada sang anak.
Schizophrenia
Abudllah dan Hamadah dari rumah sakit di London menemukan bahwa pada penderita schizophernics umumnya mengalami kekurangan DGLA yang banyak dapat diperoleh dari Evening Primrose Oil. Pengobatan menggunakan Evening Primrose Oil pada penderita schizophrenics dapat membantu mengurangi gejala emosi tidak stabil, anti-social, kurang dapat mengekspresikan diri dan gangguan interaksi sosial.
Menjaga kesehatan hati bagi alkoholik
Evening Primrose Oil sangat baik untuk dikonsumsi oleh penderita alkoholic, dimana membantu menjaga kesehatan hati agar tidak mengalami kerusakan hati.
KETERANGAN BAHASA INGGRIS
Oenothera Biennis L. - Evening Primrose (EP) was konwn as an efficient drug in ancient time by American Indian. It was transmigrated to Europe after the 17th Century. The European regarded it as the ??ingdom drug??at that time. However, nobody knew the secret of its mechanism of action. Until 1960s, after the discovery of prostaglandin (PG), it has been understood that the good effcieccy of EP oil is due to its rich content of linoleic acid (more than 70%) and Gamma-linolenic acid (GLA7-9%); especially the latter, which is the precursor of PGE, which offers potent inhibitory effect on platelet aggregation and vasoconstriction. The linoleic and Gamma-linolenic acids are unsaturated fatty acid. They possess biological activities, but cannot be biosynthesized inside human body, and are therefore considered as essential fatty acids (EFA).
The EFAs are important composition of cell membrane and precursor of a potent biological active substance (prostaglandin). Therefore, deficiency of EFAs will lead to pro-found disturbance in tissues and organs. Normally, people ingest enough alpha-linoleic acid which can be converted into GLA by a 6-delta-desaturase; in turn, GLA can be converted to dihomo-gamma-linolenic acid (DGLA), which can be further converted into PGE, which is an endogenous cardiovascular protector.
Experiments have evidently proved that PGEi can inhibit platelet aggregation and thromboxane (TXAz) formation. EP oil and DGLA also possess the same effects. Their rate of inhibition are 43.8%, 48.9% and 72.8%, 72.5% respectively.
Now, it is confirmed that TXA2 formed in platelets is a potent thrombogenic PG, which causes vessel constriction and platelet aggregation; on the contrary, prostacyclin (PGI2) formed by vascular endothelium, relaxes vascular smooth muscles and inhibits platelet aggregation. Now, the widely accepted concept is that the ratio of TXA3/PGI2 is closely related to the maintenance of normal internal environment of cardiovascular system. An increase of TXA2 or TXA3/PGI2 ratio can lead to thrombosis and atheriosclerosis.
Activity of delta-6-desaturase decreases in aging people, and therefore, alpha- linoleic acid can hardly be converted into GLA, which results in deficiencies of GLA, DGLA and also PGEi.
CLINICAL OBSERVATIONS:
ARTERIOSCLEROSIS AND CORONARY HEART DISEASE
We had proved that PGE, can effectively inhibit experimentally induced atheromatosis formation in rabbits. Matinow MR reported that EFAs not only inhibit atheromatosis formation, decrease blood pressure, but also induce the reverse processes. During the past ten years, mortality of Americans caused by coronary heart disease have decreased by 20 to 25% due to the increased proportion of polyunsaturated fatty acids in diet. Meanwhile, the proportion of GLA in fat tissues of Americans has increased. Oral administration of 3g of EP oil could increase plasma DGLA content by 6 to 9 times. Our observation on 228 patients with hyperlipemia showed that after 4 to 6 weeks administration of 1.8-2.4g EP oil daily, their serum cholesterol, triglycerides and low density lipoprotein decreased undoubtedly, high density lipoprotein increased definitely, and their platelet aggregation ability decreased evidently. The mean value of decrease was 55.3%.
PERIPHERAL VASCULAR DISEASE
EP Oil can improve exercise tolerance in a group of individuals with intermittent claudication because of vascular obstruction. PGE, is a potent vasodilator, producing dramatic improvement in patients with vascular spasm due to Raynaud?? syndrome and relieve angina pectoris in humans. These were observed in our polyclinics.
DIABETES MELLITUS
In animals with diabetes mellitus, delta-6-desaturase activity is inhibited. Furthermore, PGE, has insulin 'like action, and can potentiate insulin effects. Therefore, diabetes could lead to a functional EFA deficiency. Recently low level of PGE, in platelet has been found in diabetic human. The cases of development of retinopathy and cardiovascular complications in EFA supplemented group was less than half of the group fed with normal diet. Our observation showed that administration of EP oil could lower blood sugar level in patients with high blood sugar.
OBESITY
EP oil supplement in psychiatric patients and some normal individuals was found to be associated with weight loss, especially if the obesity is due to metabolic abnormalities. These results were also probed by our observations. Recently, a lot of Japanese actresses praised EP oil for making their skin younger, decreasing their body weight and giving them beauty and happiness.
PREMENSTRUAL SYNDROME
Results of study on 68 women with severe premenstrual syndrome in St. Thomas Medical School showed that EP oil caused two thirds of them to exhibit complete remission of all symptoms and another 22% having a partial response. 26 out of 36 women with cyclic premenstrual breast pain experienced complete relief.
ATOPIC ECZEMA
Patients taking part in two large studies of 12 weeks treatment of eczema produced a highly significant response to EP oil compared to placebo. Eczema often develops in children switching from breast feeding to bottle feeding because breast milk contains GLA. It may be possible that some eczemal patients are inefficient in converting linoleic acid to GLA.
PSYCHIATRIC DISORDERS:
SCHIZOPHRENIA
Abdulla and Hamadah from Gay?? Hospital in London reported that platelets from schizophrenics are deficient in one series of prostaglandins formed from DGLA. Treatment of schizophrenics with EP oil may improve symptoms of flat emotion and social withdrawal, and produces an expression of emotion and social interaction.
ALCOHOLISM
Alcohol enhances the conversion of DGLA to PGE i. PGE l level is elevated in mania condition which resembles acute alcoholism into excitation. The effect of alcohol in stimulating PGE l synthesis will tend to deplete DGLA stores. Alcohol also blocks delta-6'desaturase, thus preventing conversion of linoleic acid to GLA. So, withdrawal of alcohol would lead to catastrophic fall in PGE l level. Therefore, either addition of PGEi or replenishment of DGLA stores by administration of EFAs should reduce the severity of withdrawal syndrome. Injection of PGEi is able to prevent liver degeneration in alcohol treated animals and fetal damage, both in animals and human.
Terakhir diperbaharui: 20 April 2019
Ditinjau Oleh : Mita Saputri Lestari, S. Farm
Referensi :
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- http://en.wikipedia.org/wiki/Prostaglandin
- Keterangan pada kemasan
- http://nccam.nih.gov/health/eveningprimrose
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INFORMASI PADA KEMASAN :
BPOM No : TI 044 311 031
Cara Pakai : Diminum sehari 3 kali, sekali minum 3 kapsul
Khasiat : Mencegah dan mengobati Arterial Sclerosis (Pengerasan pembuluh arteri), Coronary Heart Disease (Penyakit Jantung Koroner), Mengurangi kemungkinan terkena diabetes dan membantu proses pengobatan Diabetes, Obesitas (kegemukan), Atopic Eczema (Penyakit Kulit), Premenstrual Syndrome (nyeri saat haid), Alcohol Intoxication (minuman alkohol berlebih) dan penundaan usia.
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Jauhkan dari jangkauan anak-anak.
Jangan digunakan jika kemasan dalam keadaan rusak.
Perhatian : Kandungannya aman digunakan tanpa adanya efek samping dan dapat digunakan sebagai suplemen
Komposisi : Pure Evening Primrose Oil?
Cara Penyimpanan : Simpan ditempat sejuk dan kering, terlindung dari cahaya matahari
Kemasan : Botol berisi 60 softgel 500mg
Diproduksi Oleh : M & A Pharmaceutical Factory Co., Ltd.
Produksi : Hong Kong
Brand : Intra Aries
Disclaimer : Hasil dapat bervariasi antara individu tergantung berbagai faktor seperti usia, genetik, pola hidup, dan lain sebagainya